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KMID : 0861020120270030001
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Korea Journal of Herbology
2012 Volume.27 No. 3 p.1 ~ p.6
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Effects of Atractylodis Rhizoma Alba extract on collagen-induced arthritis in mice
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Kim Song-Hee
Park Yong-Ki
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Abstract
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Objectives: The present study was undertaken to evaluate whether Atractylodis Rhizoma Alba ethanol (ARA-E)
extract, which is the pericarp of Atractylodes japonica Koidz. has an effect on collagen-induced arthritis (CIA)
in mice.
Methods: Male DBA/1J mice were induced by intradermal injection of bovine collagen-II in Freund’s incomplete
adjuvant (IFA). The CIA mice in the onset of arthritis were treated daily with oral administration of ARA-E
extract at dose of 50 ㎎/㎏/bw for 28 days. Arthritis index, histopathological changes and the levels of
anti-type II collagen (CII) IgG and inflammatory cytokine, TNF-α in sera of mice were measured to evaluate
the antiarthritic effect of ARA-E.
Results: ARA-E extract significantly decreased the arthritic scores and inhibited pathological changes of knee
joint tissues in CIA mice. ARA-E extract also significantly decreased the serum levels of anti-CII IgG and
TNF-α in CIA mice. These results indicate that ARA-E extract may effectively prevent arthritic damages in
CIA mice, at least partially, by inhibiting the production of autoantibodies and inflammatory cytokine.
Conclusions: This studies suggest that ARA-E has a therapeutic potential in inflammatory joint diseases such
as rheumatoid arthritis.
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KEYWORD
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Atractylodis Rhizoma Alba, Atractylodes japonica, anti-arthritic effect, collagen-induced arthriis
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